Psychological distress in the workplace: The indirect contribution of work organization conditions to work performance.

BACKGROUND: Psychological distress affects between 5 and 27% of the general population [1]. Workers facing stressful work conditions are especially at high risk for experiencing psychological distress [1]. OBJECTIVES: To evaluate the association between work organization conditions and work performance via psychological distress. While the individual contribution of work organization conditions to psychological distress and work performance has been examined in the scientific literature, their combined influence on work performance remains relatively unknown. METHODS: To adjust for design effects, we relied on cluster sampling (employees working in organizations). MPlus was used to conduct path analyses [2]. RESULTS: While psychological demands, number of hours worked, and job insecurity were positively associated with psychological distress, job recognition was negatively associated with it. In the same vein, irregular work schedules and job insecurity seem to be negatively associated with work performance. On the one hand, skill utilization, decision latitude, recognition, and job promotion, all seemed to be positively associated with employee's work performance. On the other hand, psychological demands, number of hours worked, and job insecurity were negatively and indirectly associated with work performance. CONCLUSIONS: Understanding the indirect association between work variables and workers' psychological distress could promote their work performance. Understanding this association could help shed light on the difficulties employees with psychological distress face while meeting their job requirements. The results of this study should serve as a reminder to intervene on work organization conditions.

Does salivary cortisol secretion mediate the association of work-related stressors with workers' depression?

PURPOSE: The purpose of this study was to verify the mediating role salivary cortisol intensity plays between work organization conditions and depression. This study simultaneously considered psychological and physiological (salivary cortisol) stress indicators on workers' depression in a single model. METHODS: We relied on cluster sampling of 341 workers in 34 Quebec establishments. Five saliva samples (on awakening, 30 min after awakening, at 2:00 p.m., 4:00 p.m., and bedtime) were collected per day. The weekly collection period spanned a period of 3 days (1 day off and 2 work days). We evaluated the main effects of work organization conditions on salivary cortisol intensity and depression, as well as the mediation effect of salivary cortisol intensity between work organization conditions and depression. To adjust for design effects, the direct and indirect (mediation) associations between the variables were evaluated while accounting for the non-independence of the data. RESULTS: Skill utilization and job insecurity were associated with salivary cortisol intensity, while psychological demands and job insecurity were associated with higher depression levels. Work-related variables were not found to have an indirect effect on depression via worker's salivary cortisol (AUC) intensity. CONCLUSION: Work-related stressors examined in this study did not indirectly affect worker's depression levels. Additional studies are necessary to be able to identify all work-related stressors that could potentially increase worker's depression levels through salivary cortisol.

A multilevel analysis of the role personality play between work organization conditions and psychological distress.

BACKGROUND: Psychological distress in the workplace is usually attributed to work-related variables as well as non-work-related variables. Individuals working in the same organization can differ in terms of their appraisal of work-related stressors and coping strategies used to face them. The present study aims to evaluate the moderating role personality plays between work organizations conditions and psychological distress in a large sample of Canadian participants working in various occupations and workplaces. METHODS: Multilevel regression analyses were conducted on a sample that followed a hierarchical structure with workers (N1 = 1958) nested in workplaces (N2 = 63). The direct contribution of workplace and personality was tested in a variance component model as a first step. Following this initial step, we introduced interaction variables by blocks of 11. Those interaction variables refer to each interaction combined with a specific personality variable. RESULTS: Psychological demands, number of hours worked, job insecurity, neuroticism, and agreeableness were associated with higher levels of psychological distress. Inversely, decision authority, job recognition, self-esteem, locus of control were associated with lower levels of psychological distress. Lastly, agreeableness played a moderating role between low social support garnered from one's supervisor and psychological distress. CONCLUSIONS: To intervene on work-related variables, organizations could reduce psychological demands, minimize the number of hours worked through job redesign, allow teleworking and encourage work schedule flexibility. To reduce job insecurity, organizations could explicitly communicate future organizational plans. In the same vein, decision authority could be targeted by reducing hierarchical steps and increasing autonomy. Lastly, the results pertaining to agreeableness stand in contrast with those of previous studies. We assumed that workers scoring high on agreeableness tend to put themselves last and please others first. These tendencies could make them more susceptible to health issues. With that said, work environments still need workers who are agreeable and nice to be around. To prevent high levels of agreeableness leading to psychological distress, training and information workshops are recommended. Those include stress management interventions and workshops pertaining to time management and relaxation techniques.

Barriers to the Use of Web-Based Mental Health Programs for Preventing Depression: Qualitative Study.

BACKGROUND: Depression has a profound impact on population health. Although using web-based mental health programs to prevent depression has been found to be effective in decreasing depression incidence, there are obstacles preventing their use, as reflected by the low rates of use and adherence. OBJECTIVE: The aims of the study are to understand the barriers to using web-based mental health programs for the prevention of depression and the possible dangers or concerns regarding the use of such programs. METHODS: BroMatters and HardHat were two randomized controlled trials (RCTs) that evaluated the effectiveness of e-mental health programs for preventing workplace depression. In the BroMatters RCT, only working men who were at high risk of having a major depressive episode were included. The participants were assigned to either the control group or 1 of 2 intervention groups. The control participants had access to the general depression information on the BroMatters website. Intervention group 1 had access to BroMatters and BroHealth-the depression prevention program. Intervention group 2 had access to BroMatters and BroHealth along with weekly access to a qualified coach through telephone calls. The HardHat trial targeted both men and women at high risk of having a major depressive episode. The participants in the intervention group were given access to the HardHat depression prevention program (which included a web-based coach), whereas HardHat access was only granted to the control group once the study was completed. This qualitative study recruited male participants from the intervention groups of the two RCTs. A total of 2 groups of participants were recruited from the BroMatters study (after a baseline interview: n=41; 1 month after the RCT: n=20; 61/744, 8.2%), and 1 group was recruited from the HardHat RCT 1 month after the initial quantitative interview (9/103, 8.7%). Semistructured interviews were performed with the participants (70/847, 8.3%) and analyzed using content analysis. RESULTS: There were both personal and program-level barriers to program use. The three personal barriers included time, stress level, and the perception of depression prevention. Content, functionality, and dangers were the program-level barriers to the use of web-based mental health programs. Large amounts of text and functionality issues within the programs decreased participants' engagement. The dangers associated with web-based mental health programs included privacy breaches and inadequate help for severe symptoms. CONCLUSIONS: There are personal and program-level barriers to the use of web-based mental health programs. The stigmatization of help seeking for depression symptoms affects the time spent on the program, as does the public perception of depression. Certain barriers may be mitigated by program updates, whereas others may require a complete shift in the perception of depression prevention.

L'influence de l'identité professionnelle sur la détresse psychologique dans les métiers spécialisés des secteurs de la construction et manufacturier au Québec.

OBJECTIVE: This study explores how the structure of professional identity and its undermining are associated with symptoms of psychological distress in the skilled trades, focusing on the construction and manufacturing sectors in Quebec. One limitation of the current research is its neglect of professional identity, even though this concept is important to explaining psychological distress symptoms. METHODS: The sample includes 282 workers from four manufacturing and seven construction sites in Quebec. Data were collected for the years 2016 and 2017. Multilevel regression analysis was carried out with the statistical software Stata 13. Five variables were controlled in this study: sex, gender, age, type of team and occupational sector. RESULTS: The results of multilevel regression models, addressing variations across 54 participating teams, suggested that a low skilled trades self-esteem, a higher professional identification, a low integration of differences, heavy demands at work, and job insecurity are associated with psychological distress, as are the factors of being a woman or being a younger worker. CONCLUSION: Study results corroborate the importance of taking preventive actions on identity dimensions to reduce psychological distress symptoms. In particular, at the level of skilled trades culture, it would be beneficial to incorporate values based on a better inclusion of all workers and an open mind with regard to differences.

RéSUMé: OBJECTIF: Cette étude explore comment la structure de l'identité professionnelle et sa fragilisation s'associent aux symptômes de détresse psychologique dans les métiers spécialisés des secteurs de la construction et manufacturier au Québec. Une limitation importante dans la littérature consiste en l'omission de l'identité professionnelle, même s'il s'agit d'un concept important pour expliquer les symptômes de détresse psychologique. MéTHODE: L'échantillon se compose de 282 travailleurs de quatre établissements manufacturiers et de sept chantiers de construction au Québec. Les données ont été collectées durant les années 2016 et 2017. Des analyses de régressions multiniveaux ont été réalisées avec le logiciel statistique Stata 13. Cinq variables ont été contrôlées dans cette étude, soit le sexe, le genre, l'âge des travailleurs, ainsi que le type d'équipe et le secteur d'occupation. RéSULTATS: Les résultats des analyses multiniveaux, en considérant la variation entre les 54 équipes, ont associé une faible estime privée du métier, un fort sentiment d'identification, une faible intégration des différences, de fortes demandes au travail et de l'insécurité d'emploi à la détresse psychologique, ainsi que le fait d'être une femme et un âge moins élevé des travailleurs. CONCLUSION: Les conclusions de cette étude corroborent l'importance d'agir sur les dimensions identitaires afin de réduire les symptômes de détresse psychologique. Particulièrement, au niveau de la culture de métiers, il s'avère judicieux de privilégier les valeurs misant sur l'inclusion des travailleurs et sur une plus grande ouverture aux différences.

Developing and maintaining the resilience of interdisciplinary cancer care teams: an interventional study.

BACKGROUND: Providing care to cancer patients is associated with a substantial psychological and emotional load on oncology workers. The purpose of this project is to co-construct, implement and assess multidimensional intervention continuums that contribute to developing the resilience of interdisciplinary cancer care teams and thereby reduce the burden associated with mental health problems. The project is based on resources theories and theories of empowerment. METHODS: The study will involve cancer care teams at four institutions and will use a mixed-model design. It will be organized into three components: (1) Intervention development. Rather than impose a single way of doing things, the project will take a participatory approach involving a variety of mechanisms (workshops, discussion forums, surveys, observations) to develop interventions that take into account the specific contexts of each of the four participating institutions. (2) Intervention implementation and assessment. The purpose of this component is to implement the four interventions developed in the preceding component, assess their effects and whether they are cost effective. A longitudinal quasi-experimental design will be used. Intervention monitoring will extend over 12 months. The effects will be assessed by means of generalized estimating equation regressions. A cost-benefit analysis will be performed to assess the cost-effectiveness of the interventions, taking an institutional perspective (costs and benefits associated with the intervention). (3) Analysis of co-construction and implementation process. The purpose of this component is to (1) describe and assess the approaches used to engage stakeholders in the co-construction and implementation process; (2) identify the factors that have fostered or impeded the co-construction, implementation and long-term sustainability of the interventions. The proposed design is a longitudinal multiple case study. DISCUSSION: In the four participating institutions, the project will provide an opportunity to develop new abilities that will strengthen team resilience and create more suitable work environments. Beyond these institutions, the project will generate a variety of resources (e.g.: work situation analysis tools; method of operationalizing the intervention co-development process; communications tools; assessment tools) that other oncology teams will be able to adapt and deploy elsewhere.

Perceived Effectiveness and Motivations for the Use of Web-Based Mental Health Programs: Qualitative Study.

BACKGROUND: The prevalence of depression is high and has been stable despite increased treatment, research, and dissemination. People encounter barriers to seeking traditional mental health services, which could be mitigated by using web-based prevention methods. OBJECTIVE: This study aims to understand what people at high risk for depression perceive as effective aspects of web-based mental health programs and what motivates people at high risk for depression to use web-based mental health programs. METHODS: We conducted an inductive content analysis using telephone interview data from 77 participants at high risk for depression who were recruited from 2 randomized controlled trials (RCTs). Participants from the first RCT were working men who had been randomly assigned to 1 of the following 3 groups: control group, who had access to general depression information from a website called BroMatters; intervention group 1, who had access to the BroMatters website along with the associated BroHealth web-based mental health program; and intervention group 2, who had access to the BroMatters website, the BroHealth web-based mental health program, and telephone sessions with a life coach. Participants from the second RCT were men and women who had been assigned to the intervention group, who received access to the HardHat web-based mental health program, or the control group, who only received access to the HardHat web-based mental health program following completion of the RCT. Participants for this inductive content analysis study were recruited from the intervention groups in both RCTs. Two groups of participants (n=41 and n=20) were recruited from the BroHealth RCT, and a third group comprised 16 participants that were recruited from the HardHat RCT. RESULTS: We generated four categories regarding the perceived effectiveness of web-based programs and five categories related to what motivates the use of web-based programs. Participants identified awareness, program medium and functionality, program content, and coaches as categories related to the effectiveness of the programs. Categories of motivators to use web-based programs included providing reminders or incentives, promotion of the programs, providing appropriate medium and functionality, appropriate content, and perceived need. The final category related to motivators reflects perceptions of participants who were either unsure about what motivates them or believed that there is no way to motivate use. CONCLUSIONS: Conflicting evidence was obtained regarding the perceived effectiveness of aspects of the content and functionality of web-based programs. In general, web-based mental health programs were perceived to help increase mental health awareness, especially when it includes live access to a coach. However, the results also revealed that it is difficult to motivate people to begin using web-based mental health programs. Strategies that may motivate the use of such programs include perceived personal need, effective promotion, providing incentives and reminders, and improving functionality.

Psychological distress inequality between employed men and women: A gendered exposure model.

This study examines an exposure model in which the work and family stressors and the access to resources are gendered and contribute to explaining the psychological distress inequality between sex categories, both directly and indirectly through work-family conflict. A multilevel path analysis conducted on a random cross-sectional sample of 2026 Canadians workers from 63 establishments was performed. Our exposure model fully explains the higher level of psychological distress among working women compared to working men. Women are more exposed to work-to-family conflict, have less decision authority, are more likely to be a single parent and have less self-esteem, factors that are directly associated with a higher level of psychological distress. On the other hand, women work fewer hours, have less irregular or evening schedules and have more social resources outside of work, which contribute to lower their level of psychological distress through less work-to-family conflict. By identifying which of the differences in exposure to work and family stressors and resources explain the greater psychological distress of working women compared to working men, and by examining the mediating role of work-family conflict in this process, this study identified specific paths to reduce psychological distress inequality between women and men in the workplace.

Targeting Catecholaminergic Systems in Transgenic Rats With a CAV-2 Vector Harboring a Cre-Dependent DREADD Cassette.

Techniques that allow the manipulation of specific neural circuits have greatly increased in the past few years. DREADDs (Designer receptors exclusively activated by designer drugs) provide an elegant way to manipulate individual brain structures and/or neural circuits, including neuromodulatory pathways. Considerable efforts have been made to increase cell-type specificity of DREADD expression while decreasing possible limitations due to multiple viral vectors injections. In line with this, a retrograde canine adenovirus type 2 (CAV-2) vector carrying a Cre-dependent DREADD cassette has been recently developed. In combination with Cre-driver transgenic animals, the vector allows one to target neuromodulatory pathways with cell-type specificity. In the present study, we specifically targeted catecholaminergic pathways by injecting the vector in knock-in rat line containing Cre recombinase cassette under the control of the tyrosine hydroxylase promoter. We assessed the efficacy of infection of the nigrostriatal pathway and the catecholaminergic pathways ascending to the orbitofrontal cortex (OFC) and found cell-type-specific DREADD expression.

Chronic diseases, age and gender: examining the contribution to burnout symptoms in a sample of 2075 Canadian workers.

PURPOSE: This cross-sectional study aims to evaluate the role of chronic diseases, and their interactions with age and gender, on the emotional exhaustion component of the burnout syndrome. METHODS: Data came from the Salveo Study conducted in 2009-2012. It contained a random sample of 2075 Canadian workers employed in 63 workplaces. Multilevel regression models were estimated. Main effects of chronic diseases were first evaluated, and then age-chronic diseases interactions were tested. Analyses were performed on the total sample and stratified by gender. All analyses were adjusted for work conditions decision latitude, physical and psychological demands, work hours, social support and rewards. RESULTS: Mental and behavioural disorders, diseases of the nervous system, the musculoskeletal system and connective tissue, and genitourinary system are associated with a higher level of burnout symptoms. Associations with mental and behavioural disorders, and diseases of the nervous system are stronger for men than women. Age increases the association of behavioural disorders, diseases of the nervous system, and genitourinary system and burnout. Age may moderate the association of nervous and genitourinary systems diseases with burnout in women. CONCLUSION: Workplaces must be more proactive to better recognise the role of chronic diseases on burnout and to implement preventive measures. The development of interventions towards specific risk groups is needed.

Does Depression Mediate the Effect of Work Organization Conditions on Job Performance?

OBJECTIVE: The present study proposes to shed light on the impact of workers' depression on their work performance. METHODS: We implemented a path analyses adjusted for design effects resulting from cluster sampling using MPlus software on a sample of 1957 workers. These analyses allowed us to evaluate direct and indirect effects (mediation) while taking into account the nonindependence of observations due to cluster sampling (workers nested in their workplace). RESULTS: Results indicate that three indirect associations were found to be significant. Psychological demands, work schedule, and job insecurity were indirectly associated with lower levels of professional efficacy/job performance because of their positive associations with depression. CONCLUSIONS: The results obtained suggest that interventions targeting specific work organization conditions could be warranted.

Work, family, work-family conflict and psychological distress: A revisited look at the gendered vulnerability pathways.

This paper revisited the vulnerability hypothesis to explain the greater level of psychological distress among working women compared to working men. A comprehensive vulnerability model was tested in which work and family stressors and psychosocial resources are directly related to psychological distress and indirectly through work-to-family (WFC) and family-to-work (FWC) conflicts. Data came from a random sample of 989 women and 1,037 men working in 63 Canadian establishments. Multilevel path analyses were performed separately for men and for women. The results show that many work/family stressors and resources are linked to men's or women's psychological distress directly and indirectly through WFC and FWC. However, the z-test used to assess whether the relationships differed significantly between women and men indicated that only two relationships differ significantly between the two groups: experimenting problems with children and a low self-esteem are associated positively to psychological distress through FWC only for women. In addition to showing the specific involvement of work-family conflict in the psychological distress inequality, this study contributes to revealing that testing the differences in the magnitude of the relation offer a more suitable appraisal of the vulnerability mechanism involved in the psychological distress inequality between men and women.

Identifying Strategies for Decreasing Work-Related Stress Among Working Men: An International Delphi Consensus Study.

OBJECTIVE: The objective was to identify helpful, feasible strategies that can be implemented by working men to decrease work-related stress. METHODS: An international Delphi consensus study was conducted with four panels of stakeholders. Three rounds of surveys were sent to panellists who rated the helpfulness and feasibility of strategies. Strategies were considered to have reached consensus if 80+% of at least three panels "agreed" or "strongly agreed" that the strategies were helpful or feasible. RESULTS: Eighty-one strategies reached consensus out of a total 127 for helpfulness in decreasing work-related stress. Eleven strategies did not reach consensus in any of the vignettes. Only two strategies reached consensus for feasibility. CONCLUSION: While many strategies are perceived as helpful for decreasing workplace stress, the feasibility of the strategies likely depends on an individual's particular needs and context.

Impacts of inter-trial interval duration on a computational model of sign-tracking vs. goal-tracking behaviour.

In the context of Pavlovian conditioning, two types of behaviour may emerge within the population (Flagel et al. Nature, 469(7328): 53-57, 2011). Animals may choose to engage either with the conditioned stimulus (CS), a behaviour known as sign-tracking (ST) which is sensitive to dopamine inhibition for its acquisition, or with the food cup in which the reward or unconditioned stimulus (US) will eventually be delivered, a behaviour known as goal-tracking (GT) which is dependent on dopamine for its expression only. Previous work by Lesaint et al. (PLoS Comput Biol, 10(2), 2014) offered a computational explanation for these phenomena and led to the prediction that varying the duration of the inter-trial interval (ITI) would change the relative ST-GT proportion in the population as well as phasic dopamine responses. A recent study verified this prediction, but also found a rich variance of ST and GT behaviours within the trial which goes beyond the original computational model. In this paper, we provide a computational perspective on these novel results.

Dopamine blockade impairs the exploration-exploitation trade-off in rats.

In a volatile environment where rewards are uncertain, successful performance requires a delicate balance between exploitation of the best option and exploration of alternative choices. It has theoretically been proposed that dopamine contributes to the control of this exploration-exploitation trade-off, specifically that the higher the level of tonic dopamine, the more exploitation is favored. We demonstrate here that there is a formal relationship between the rescaling of dopamine positive reward prediction errors and the exploration-exploitation trade-off in simple non-stationary multi-armed bandit tasks. We further show in rats performing such a task that systemically antagonizing dopamine receptors greatly increases the number of random choices without affecting learning capacities. Simulations and comparison of a set of different computational models (an extended Q-learning model, a directed exploration model, and a meta-learning model) fitted on each individual confirm that, independently of the model, decreasing dopaminergic activity does not affect learning rate but is equivalent to an increase in random exploration rate. This study shows that dopamine could adapt the exploration-exploitation trade-off in decision-making when facing changing environmental contingencies.

Men's Work-Related Stress and Mental Health: Illustrating the Workings of Masculine Role Norms.

Although a strong relationship between employment and men's mental health has been identified, theoretical linkages between masculinity, employment, and mental health are not well developed and mental health supports that account for gender and employment are correspondingly inadequate. The purpose of this study is to contribute to theoretical understandings of men's employment-related mental health experience and raise possibilities for gender-responsive employer supports for men's mental health. Specifically, this study is a secondary analysis of narrative accounts from 18 men employed in male-dominated occupations about their employment-related mental health. Results of this study present evidence of processes by which theoretical concepts of masculine role norms influence work-related stress and mental health including: (a) injunctive norms, which operate through an internal sense of the cultural "shoulds" and "should nots"; (b) descriptive norms, which are communicated through the behaviors that a man sees other men enacting in his immediate environment; and (c) cohesive norms, which exert influence through observations of how men who are leaders, behave. Men's insights into the complexity of employment-related stress and mental health according to masculine role norms related to work demands and leadership modeling and messaging are discussed. This study concludes with potential ways forward for employer support for men's mental health.

High cortisol awakening response in the aftermath of workplace violence exposure moderates the association between acute stress disorder symptoms and PTSD symptoms.

Although a majority of people will be exposed to a traumatic event over the course of their lifespan, only a minority will develop post-traumatic stress disorder. Better understanding the factors contributing to the development of this psychopathology is of high importance and could significantly reduce the societal and human costs associated with PTSD. Acute stress disorder symptoms, which refers to clinical manifestations experienced in the aftermath of a traumatic event, have been shown to be associated with subsequent PTSD symptoms. Yet, many people who develop PTSD do not meet criteria for acute stress disorder in the first place, highlighting the need to refine the predictors of PTSD. The secretion of the stress hormone cortisol is dysregulated in PTSD patients. Whether combining clinical and biological measures in the aftermath of trauma could help to better explain subsequent PTSD symptoms remains to be tested. The current prospective study recruited 51 adults who were exposed to a traumatic event in their work setting, i.e. a psychiatric hospital. Acute stress disorder symptoms and cortisol awakening responses were assessed one to five weeks following trauma exposure (Time 1). PTSD symptoms were measured two months following trauma exposure. Results revealed a significant interaction between acute stress disorder symptoms and cortisol awakening response in predicting later PTSD symptoms. The results suggest that higher cortisol awakening response is a protective factor in that it abolishes the relationship between acute stress disorder symptoms and subsequent PTSD symptoms. These results point to the importance of considering multi-level information in the aftermath of trauma, such as clinical and biological measures, in order to better identify individuals who are at higher risk of developing PTSD.

Les traits d'identité culturelle en lien avec le statut d'immigrant et l'ethnicité : quel lien avec les symptômes de détresse psychologique et les symptômes dépressifs dans la main-d'œuvre canadienne? Résultats des neuf cycles de l'ENSP.

PURPOSE: This study investigated variations over time of psychological distress and depressive symptoms among working Canadians according to two cultural identity traits: ethnicity and immigration status. METHOD: Data came from the nine cycles of the National Population Health Survey (NPHS) conducted by Statistics Canada. Based on a sample of 7069 workers, multiple regressions analyses and multilevel regressions models were carried out. Analyses were adjusted for confounders such as age, gender, marital status, household income, social support outside the workplace, level of education, presence of children between 0 and 5 years of age and presence of children from 6 to 11 years of age. RESULTS: Over time, and after accounting for potential confounders, immigration status is not associated with psychological distress or depressive symptoms. Ethnicity is associated with depressive symptoms, but not with psychological distress symptoms. Visible minorities have less depressive symptoms compared to Caucasians. CONCLUSION: Unlike immigration status, ethnicity seems to explain a portion of mental health inequities among workers. One area to be explored in future researches is whether in the Canadian workforce, work conditions could explain ethnic inequalities in mental health.

Distinct regional patterns in noradrenergic innervation of the rat prefrontal cortex.

The anatomy and functions of the rodent prefrontal cortex (PFC) have been extensively studied. It is now clear that the PFC is at the core of various executive functions and that these functions depend on monoaminergic neuromodulation. The PFC receives extensive projections from monoaminergic nuclei and, in particular, from the locus cœruleus (LC) which is the major source of noradrenaline (NA) in the cortex. Projections of this nucleus have long been considered to act diffusely and uniformly throughout the entire brain. However, recent studies have revealed a separate innervation of prefrontal sub-regions by non-collateralizing LC neurons, suggesting a specific modulation of their functions. Following this idea, we aimed at describing more precisely the pattern of noradrenergic innervation into different orbital (OFC) and medial (mPFC) sub-regions of the PFC. We focused on the lateral (LO), ventral (VO) and medial (MO) portions of the OFC, and on areas 32d (A32d), 32v (A32v) and 25 (A25) in the mPFC. Using Dopamine-ß-Hydroxylase as a specific noradrenergic marker, we performed an automatic quantification of noradrenergic fibers and varicosities in each of these sub-regions. The results indicate that noradrenergic innervation is heterogeneous in some prefrontal sub-regions along the rostro-caudal axis. Functional dissociations have been recently reported in prefrontal sub-regions along the rostro-caudal direction. Our findings add neuroanatomical support to this emergent idea.

Gender differences on mental health, work-family conflicts and alcohol use in response to abusive supervision / Diferencias de género en salud mental, conflictos familia-trabajo y consumo de alcohol como respuesta a la supervisión abusiva

This study aimed to examine gender effects on the relations between abusive supervision and mental health issues, work-family conflicts, as well as the risk of alcohol use. A subset of the SALVEO data (N = 2,058) was used in this paper to conduct multilevel regression analysis, controlling for both work and non-work related determinants. Results showed that abusive supervision was positively related to psychological distress and work-family conflicts, but not the risk of alcohol use. There were no gender differences found in our study, except for psychological distress. Comparing to men, abusive supervision had a stronger negative effect on women's psychological distress. Both work and non-work determinants had significant contributions to mental health issues, work-family conflicts, as well as the risk of alcohol abuse. This study illustrated the importance of using multilevel approach to examine the negative impact of abusive supervision

Este estudio tuvo como objetivo examinar los efectos del género en las relaciones entre la supervisión abusiva y las cuestiones de salud mental, los conflictos familia-trabajo, así como el riesgo de consumo de alcohol. Un subconjunto de los datos de SALVEO (N = 2,058) se utilizó en este trabajo para realizar un análisis de regresión multinivel, controlando tanto los determinantes relacionados con el trabajo, como los no relacionados con éste. Los resultados mostraron que la supervisión abusiva se relacionó positivamente con la angustia psicológica y los conflictos familia-trabajo, pero no con el riesgo de consumo de alcohol. No se encontraron diferencias de género en nuestro estudio, a excepción de la angustia psicológica. Si se compara con los hombres, la supervisión abusiva tuvo un efecto negativo más fuerte sobre la angustia psicológica de las mujeres. Tanto los factores determinantes del trabajo, como los que no lo son, contribuyeron significativamente a desarrollar problemas de salud mental, conflictos trabajo-familia, así como al riesgo de abuso de alcohol. El estudio ilustra la importancia de utilizar un enfoque multinivel para examinar el impacto negativo de la supervisión abusiva